LAUGHTON, Charles A.: search on Z-Library

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1

Force-induced melting of a short DNA double helix

Lisa H. Pope, Martyn C. Davies, Charles A. Laughton, Clive J. Roberts, Saul J.B. Tendler, Philip M. Williams

Journal:

European Biophysics Journal

Year:

2001

Language:

english

File:

PDF, 204 KB

english, 2001

2

8. CORRESPONDENCE

Frost, Cecil, Watt, Marjorie Campbell, Talbot, R. W., White, Charles M. N., Plowes, Darrel, Cooke, Audrey, Ffytche-Hogg, I. M., Clay, G. C. R., Guy, Robin, Calder, David R., Skead, C. J., Laughton, E.

Journal:

Ostrich / Journal of African Ornithology

Year:

1944

Language:

english

File:

PDF, 402 KB

english, 1944

3

In silico screening for solid dispersions: the trouble with solubility parameters and χFH

Turpin, Eleanor, Taresco, Vincenzo, Al-Hachami, Wathiq, Booth, Jonathan, Treacher, Kevin, Tomasi, Simone, Alexander, Cameron, Burley, Jonathan C, Laughton, Charles A., Garnett, Martin C.

Journal:

Molecular Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

4

Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water

Barratt, Elizabeth, Bingham, Richard J., Warner, Daniel J., Laughton, Charles A., Phillips, Simon E. V., Homans, Steve W.

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 359 KB

english, 2005

5

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

Rebeka Sultana, Daniel R. McNeill, Rachel Abbotts, Mohammed Z. Mohammed, Malgorzata Z. Zdzienicka, Haitham Qutob, Claire Seedhouse, Charles A. Laughton, Peter M. Fischer, Poulam M. Patel, David M. Wil

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

6

Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling

Hong, Wei, Li, Jingyang, Laughton, Charles A., Yap, Lee Fah, Paterson, Ian C., Wang, Hao

Journal:

Journal of Molecular Graphics and Modelling

Year:

2014

Language:

english

File:

PDF, 7.08 MB

english, 2014

7

Multiple Objectives In Undergraduate Social Welfare Programs: Problems and Issues

CHARLES W. LAUGHTON

Journal:

Journal of Education for Social Work

Year:

1968

Language:

english

File:

PDF, 1.08 MB

english, 1968

8

Long-range correlations in the mechanics of small DNA circles under topological stress revealed by multi-scale simulation

Sutthibutpong, Thana, Matek, Christian, Benham, Craig, Slade, Gabriel G., Noy, Agnes, Laughton, Charles, K. Doye, Jonathan P., Louis, Ard A., Harris, Sarah A.

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 1.55 MB

english, 2016

9

Structural studies on bioactive compounds. Part 29: Palladium catalysed arylations and alkynylations of sterically hindered immunomodulatory 2-amino-5-halo-4,6-(disubstituted)pyrimidines

Duncan R. Hannah, Edward C. Sherer, Roy V. Davies, Roger B. Titman, Charles A. Laughton, Malcolm F.G. Stevens

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 241 KB

english, 2000

10

Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly( N -methylpyrrole) Conjugates

Wells, Geoff, Martin, Christopher R. H., Howard, Philip W., Sands, Zara A., Laughton, Charles A., Tiberghien, Arnaud, Woo, Chi Kit, Masterson, Luke A., Stephenson, Marissa J., Hartley, John A., Jenkin

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1.11 MB

english, 2006

11

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity

Laughton, Charles A., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 870 KB

english, 1990

12

Simulation of 125 I-based radioprobing experiments to study DNA quadruplex structure and topology

Girard, Peter M., Nikjoo, Hooshang, Laughton, Charles

Journal:

International Journal of Radiation Biology

Year:

2008

Language:

english

File:

PDF, 517 KB

english, 2008

13

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications.

Taresco, Vincenzo, Suksiriworapong, Jiraphong, Styliari, Ioanna, Argent, Richard Harry, Swainson, Sadie May Ella, Booth, Jonathan, Turpin, Eleanor Rose, Laughton, Charles A, Burley, Jonathan C., Alexa

Journal:

Year:

2016

Language:

english

File:

PDF, 857 KB

english, 2016

14

Tios: The Internet of Simulations. Turning Molecular Dynamics into a Data Streaming Web Application.

Meletiou, Athina, Gebbie-Rayet, James T, Laughton, Charles A.

Journal:

Journal of Chemical Information and Modeling

Year:

2019

File:

PDF, 2.44 MB

2019

15

Factors involved in guanine/cytosine (G/C) selectivity of DNA-binding drugs: a molecular modelling study of ligand interactions with a tyrT DNA sequence

Greenidge, Paulette A., Laughton, Charles A., Jenkins, Terence C., Neidle, Stephen

Journal:

Journal of the Chemical Society Faraday Transactions

Year:

1993

Language:

english

File:

PDF, 771 KB

english, 1993

16

Forum

Girard, Peter M., Nikjoo, Hooshang, Laughton, Charles

Journal:

Year:

2006

Language:

english

File:

PDF, 779 KB

english, 2006

17

pyPcazip: A PCA-based toolkit for compression and analysis of molecular simulation data

Shkurti, Ardita, Goni, Ramon, Andrio, Pau, Breitmoser, Elena, Bethune, Iain, Orozco, Modesto, Laughton, Charles A.

Journal:

Year:

2016

Language:

english

File:

PDF, 833 KB

english, 2016

18

Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors

Sartori, Geraldo Rodrigues, LeitÃ£o, Andrei, Montanari, Carlos A., Laughton, Charles A., Salsbury, Freddie

Journal:

Year:

2019

File:

PDF, 809 KB

2019

19

Sterically hindered analogues of diacylglycerols. synthesis, binding to the phorbol ester receptor and metabolism in a549 human lung carcinoma cells

Charles A. Laughton, Tracey D. Bradshaw, Andreas Gescher

Journal:

International Journal of Cancer

Year:

1989

Language:

english

File:

PDF, 512 KB

english, 1989

20

Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

David F. Burke, Charles A. Laughton, Chris F. Snook, Stephen Neidle, Gerard A. Potter, Michael Jarman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 228 KB

english, 1995

21

Antitumor Polycyclic Acridines. 8. 1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts

Heald, Robert A., Modi, Chetna, Cookson, Jenny C., Hutchinson, Ian, Laughton, Charles A., Gowan, Sharon M., Kelland, Lloyd R., Stevens, Malcolm F. G.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 217 KB

english, 2002

22

Molecular Dynamics Study of Oligonucleotides Containing Difluorotoluene

Cubero, Elena, Laughton, Charles A., Luque, F. Javier, Orozco, Modesto

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 489 KB

english, 2000

23

Correction: Development of a series of bis-triazoles as G-quadruplex ligands

Saleh, Maysaa M., Laughton, Charles A., Bradshaw, Tracey D., Moody, Christopher J.

Journal:

Year:

2017

Language:

english

File:

PDF, 133 KB

english, 2017

24

Experimental Study and Computational Modelling of Cruzain Cysteine Protease Inhibition by Dipeptidyl Nitriles

dos Santos, Alberto Monteiro, Cianni, Lorenzo, De Vita, Daniela, Rosini, Fabiana, Leitao, Andrei, Laughton, Charles A, Lameira, Jeronimo, Montanari, Carlos

Journal:

Physical Chemistry Chemical Physics

Year:

2018

Language:

english

File:

PDF, 2.29 MB

english, 2018

25

Antitumor Polycyclic Acridines. Part 16. Triplex DNA as a Target for DNA-Binding Polycyclic Acridine Derivatives

Missailidis, Sotiris, Modi, Chetna, Trapani1, Valentina, Laughton, Charles A., Stevens, Malcolm F. G.

Journal:

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

26

Structural Studies on Bioactive Compounds. Part 36: Design, Synthesis and Biological Evaluation of Pyrimethamine-Based Antifolates Against Pneumocystis carinii

David C.M. Chan, Charles A. Laughton, Sherry F. Queener, Malcolm F.G. Stevens

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 311 KB

english, 2002

27

Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of α/γ Conformers

Alberto Pérez, Iván Marchán, Daniel Svozil, Jiri Sponer, Thomas E. Cheatham III, Charles A. Laughton, Modesto Orozco

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 1.52 MB

english, 2007

28

Cooperativity in Drug−DNA Recognition: A Molecular Dynamics Study

Harris, Sarah A., Gavathiotis, Evripidis, Searle, Mark S., Orozco, Modesto, Laughton, Charles A.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 659 KB

english, 2001

29

A Crystallographic and Spectroscopic Study of the Complex between d(CGCGAATTCGCG) 2 and 2,5-Bis(4-guanylphenyl)furan, an Analogue of Berenil. Structural Origins of Enhanced DNA-Binding Affinity †

Laughton, Charles A., Tanious, Farial, Nunn, Christine M., Boykin, David W., Wilson, W. David, Neidle, Stephen

Journal:

Year:

1996

Language:

english

File:

PDF, 721 KB

english, 1996

30

Molecular Dynamics Studies of DNA A-Tract Structure and Flexibility

Sherer, Edward C., Harris, Sarah A., Soliva, Robert, Orozco, Modesto, Laughton, Charles A.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

31

Development of a series of bis-triazoles as G-quadruplex ligands

Saleh, Maysaa M., Laughton, Charles A., Bradshaw, Tracey D., Moody, Christopher J.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

32

Dipeptidyl nitrile derivatives have cytostatic effects against Leishmania spp. promastigotes

Quilles, José C., Tezuka, Daiane Y., Lopes, Carla D., Ribeiro, Fernanda L., Laughton, Charles A., de Albuquerque, Sérgio, Montanari, Carlos A., Leitão, Andrei

Journal:

Experimental Parasitology

Year:

2019

Language:

english

File:

PDF, 1.47 MB

english, 2019

33

A Study of CDK2 Inhibitors Using a Novel 3D-QSAR Method Exploiting Receptor Flexibility

Michael P. Mazanetz, Ian M. Withers, Charles A. Laughton, Peter M. Fischer

Journal:

Molecular Informatics

Year:

2009

Language:

english

File:

PDF, 281 KB

english, 2009

34

Rationally Designed Analogs of Tamoxifen with Improved Calmodulin Antagonism

Hardcastle, Ian R., Rowlands, Martin G., Houghton, John, Parr, Iris B., Potter, Gerard A., Jarman, Michael, Edwards, Karen J., Laughton, Charles A., Trent, John O., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.61 MB

english, 1995

35

Molecular Dynamics Simulations of the Adenosine A2a Receptor in POPC and POPE Lipid Bilayers: Effects of Membrane on Protein Behavior

Ng, Hui Wen, Laughton, Charles A., Doughty, Stephen W.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

36

Quality Assurance for Biomolecular Simulations

Murdock, Stuart E., Tai, Kaihsu, Ng, Muan Hong, Johnston, Steven, Wu, Bing, Fangohr, Hans, Laughton, Charles A., Essex, Jonathan W., Sansom, Mark S. P.

Journal:

Journal of Chemical Theory and Computation

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

37

Determination of DNA structural detail using radioprobing

Girard, Peter M., Laughton, Charles, Nikjoo, Hooshang

Journal:

International Journal of Radiation Biology

Year:

2012

Language:

english

File:

PDF, 764 KB

english, 2012

38

Certain Imidazotetrazines Escape O6-Methylguanine-DNA Methyltransferase and Mismatch Repair

Zhang, Jihong, Stevens, Malcolm F.G., Hummersone, Marc, Madhusudan, Srinivasan, Laughton, Charles A., Bradshaw, Tracey D.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

39

Production and characterization of an anti-(MUC1 mucin) recombinant diabody

Graeme Denton, Kevin Brady, Benny K. C. Lo, Andrea Murray, C. Rosamund, L. Graves, Owen D. M. Hughes, Saul J. B. Tendler, Charles A. Laughton, Michael R. Price

Journal:

Cancer Immunology, Immunotherapy

Year:

1999

Language:

english

File:

PDF, 311 KB

english, 1999

40

Molecular Dynamics Simulation of a PNA·DNA·PNA Triple Helix in Aqueous Solution

Shields, George C., Laughton, Charles A., Orozco, Modesto

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 245 KB

english, 1998

41

Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analog, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives

Laughton, Charles A., McKenna, Robert, Neidle, Stephen, Jarman, Michael, McCague, Ray, Rowlands, Martin G.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 854 KB

english, 1990

42

Identification of the PcrA DNA helicase reaction pathway by applying advanced targeted molecular dynamic simulations

Wang, Hao, Hong, Wei, Paterson, Ian C., Pu, Jing, Laughton, Charles A.

Journal:

Molecular Simulation

Year:

2014

Language:

english

File:

PDF, 489 KB

english, 2014

43

Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides

Bates, Paula J., Macaulay, Valentine M., McLean, Michael J., Jenkins, Terence C., Reszka, Anthony P., Laughton, Charles A., Neidle, Stephen

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 6.25 MB

english, 1995

44

Exploiting glycogen synthase kinase 3β flexibility in molecular recognition

Mazanetz, Michael P., Withers, Ian M., Laughton, Charles A., Fischer, Peter M.

Journal:

Biochemical Society Transactions

Year:

2008

File:

PDF, 2 KB

2008

45

Rapid Nanogram Scale Screening Method of Microarrays to Evaluate Drug–Polymer Blends Using High-Throughput Printing Technology

Taresco, Vincenzo, Louzao, Iria, Scurr, David, Booth, Jonathan, Treacher, Kevin, McCabe, James, Turpin, Eleanor, Laughton, Charles A., Alexander, Cameron, Burley, Jonathan C., Garnett, Martin C.

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

46

Molecular Dynamics Simulations of Duplex Stretching Reveal the Importance of Entropy in Determining the Biomechanical Properties of DNA

Harris, Sarah A., Sands, Zara A., Laughton, Charles A.

Journal:

Biophysical Journal

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

47

Evaluation of molecular modelling methods to predict the sequence-selectivity of DNA minor groove binding ligands

Wang, Hao, Laughton, Charles A.

Journal:

Physical Chemistry Chemical Physics

Year:

2009

Language:

english

File:

PDF, 1.18 MB

english, 2009

48

The study of interactions between DNA and PcrA DNA helicase by using targeted molecular dynamic simulations

Wang, Hao, Cui, Jiajia, Hong, Wei, Paterson, Ian C., Laughton, Charles A.

Journal:

Journal of Molecular Modeling

Year:

2013

Language:

english

File:

PDF, 844 KB

english, 2013

49

Nanoformulation-by-design: an experimental and molecular dynamics study for polymer coated drug nanoparticles

Styliari, Ioanna Danai, Taresco, Vincenzo, Theophilus, Andrew, Alexander, Cameron, Garnett, Martin, Laughton, Charles

Journal:

Year:

2020

File:

PDF, 776 KB

2020

50

Multiple Objectives In Undergraduate Social Welfare Programs

Laughton, Charles W.

Journal:

Journal of Education for Social Work

Year:

1968

Language:

english

File:

PDF, 4.32 MB

english, 1968

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